Jobs in Structural Biology and Related Fields


Post-doctoral positions to investigate and develop a novel class of efflux pump inhibitors in Gram-negative bacteria


Institute of Biochemistry Goethe University of Frankfurt, Frankfurt, Germany
Application deadline: 31 Dec 2019


An international (French/German) collaborative research program has recently been funded (ANR/BMBF) to investigate and develop a novel class of efflux pump inhibitors in Gram-negative bacteria. The project aims to fully elucidate the mechanism of action of the efflux pump inhibitors, understand the structural biology and perform medicinal chemistry to develop the inhibitors into drug like molecules for in vivo proof of concept. The bacteria of interest are E. coli, K. pneumoniae, A. baumannii and P. aeruginosa.

This application concerns a postdoctoral researcher position at the Institute of Biochemistry, in the department of Membrane Transport Machineries (Prof. Dr. Klaas M. Pos) and a postdoctoral researcher position at the Institute of Biophysics in the department of Cryo-Electron Microscopy (Prof. Dr. Achilleas Frangakis) at the Goethe University Frankfurt, Germany. In these closely collaborating teams, the research focus will be to define the molecular determinants of efflux pump inhibitor binding and its mechanism of action using X-ray crystallography, single-particle electron microscopy, Cryo-electron tomography, as well as molecular biology and biochemistry.

The applicants are required to have a PhD in biochemistry and/or structural biology. Candidates must have demonstrated profound research experience in structure solution of membrane proteins by X-ray crystallography and/or single-particle Cryo-EM and/or Cryo-ET. It is essential that the candidates are able to work efficiently in the context of an international collaboration and interact with microbiology and chemistry collaborators. Candidates must have a publication record in good and relevant scientific journals.

For interested candidates: please send a CV (listing education, research skills and publications) and a focused letter of motivation to pos@em.uni-frankfurt.de

Deadline: December 31st, 2019

The positions are available from the beginning of March 2020 for up to 3 years.

 

For more information about the department, click here.

Frankfurt, Germany

Post-doctoral positions to investigate and develop a novel class of efflux pump inhibitors in Gram-negative bacteria