Jobs in Structural Biology and Related Fields


Post-doctoral Research Fellow: Protein Chemistry/Structural Biology


University of Leeds, Leeds, United Kingdom
Application deadline: 12 May 2013


Applications are invited for an ERC-funded postdoctoral research assistant to join a dynamic, interdisciplinary team focusing on the use of biophysical, biochemical and cell biological methods to investigate the structural molecular mechanisms of protein aggregation into amyloid fibrils in vitro and the effects of aggregated/disaggregated species on cellular homeostasis. This large programme involves collaboration between the groups of Professor Sheena Radford and Drs David Brockwell, Neil Ranson, Eric Hewitt and Prof Alison Ashcroft within the Astbury Centre for Structural Molecular Biology. Ultimately, the programme of research will involve the appointment of four post-doctoral fellows.

You will focus on the use of biophysical methods to determine the structure, stability and dynamics of amyloid fibrils and their precursors and how these are affected by interaction with biological membranes. You will be a protein chemist, with experience in the analysis of protein structure and assembly using biophysical approaches. An appointment will be made for a related position (FBSMB0007) which will bring complementary expertise in the use of single molecule force and imaging AFM techniques to study protein-protein interactions.

You will have (or be close to completing) a PhD in biochemistry, chemistry, physics or a related discipline. Experience in protein structure analysis, protein chemistry and molecular biology is also essential.

University Grade 7 (£30,424 – £36,298 p.a.)

Informal enquiries may be made to Professor Sheena E Radford, email s.e.radford@leeds.ac.uk, Professor Alison Ashcroft, email a.e.ashcroft@leeds.ac.uk or Dr David Brockwell, email d.j.brockwell@leeds.ac.uk

Closing Date: 12 May 2013

Ref: FBSMB0006

Fixed term for 3 years from 1 May 2013 (with possible extension to 4 or 5 years subject to funding)

ERC Advanced Grant “Amyloid Fibril Cytotoxicity: New Insights from Novel Approaches”

For further information and application details, please click here.