The group of Dr. Francesca Mattiroli currently has a vacancy for a Postdoc to work on the mechanism of epigenome inheritance.
Proper inheritance of the epigenetic information during cell division controls cell fate and survival, and it is crucial for disease avoidance. We have little understanding however of the mechanisms by which epigenetic information, specifically histone post-translational modifications in nucleosomes, are replicated in parallel to the DNA prior to cell division. The process strictly depends on proper nucleosome assembly on the newly synthesized DNA strands. The Mattiroli lab studies the molecular mechanism of nucleosome assembly during DNA replication.
The postdoctoral fellow will use structural, biochemical and cell-based approaches to elucidate the key players of this pathway, their activity, interactions and their downstream effects. The focus will be at the interface between DNA synthesis and nucleosome assembly functions.
For more information and to apply, click here.