The Rosenberg lab, located at University of California - San Francisco (UCSF) and affiliated with the Chan-Zuckerberg Biohub, has an NIH funded position for a postdoctoral scholar to continue our work characterising the structural biology of host-pathogen interactions. You will have exciting opportunities to combine your structural findings with functional characterisation using microbial genetics. In recent work, the lab have used a variety of structural techniques to characterise bacterial virulence systems (see for example, PMID: 31886769, PMID: 28252385, or PMID: 25865481). We have also developed novel genetic tools that can be used to study how pathogens interact with their hosts (PMID: 30617347, PMID: 31481541, or PMID: 31073154).
The ideal candidate will have a PhD and be trained in electron microscopy or x-ray crystallography and with an interest in expanding their structural tool kit. The facilities at UCSF include access to a Talos Arctica Cryo-TEM for screening and a Krios with a K3 bioquantum for data collection, as well as several other instruments for negative stain and additional data collection. New funding has also been obtained for the installation of a Cryo-FIB and a cryo-fluorescence microscope to facilitate CryoCLEM. Additionally, there is a state-of-the-art, automated facility for protein crystal growth, and essentially unlimited access to synchrotron time at ALS. Many shared instruments are available for biophysical characterisation of proteins.
If you are interested, please contact Laura Wise (Laura.Wise@ucsf.edu) with a cover letter and a CV describing your work and we will be in touch! Please submit your application before 1 April 2020 for full consideration, though the start date is negotiable.
