A postdoctoral vacancy is available between the Universities of Manchester and Leeds, within an active and well-funded research team to investigate the structure and function of multi-molecular complexes responsible for extracellular matrix organisation in the context of inflammatory processes and reproductive biology.
The project will use cryo-electron microscopy (cryoEM), in combination with other quantitative biophysical techniques, to determine the high-resolution structures of protein complexes that act as 'crosslinking nodes', which stabilise matrices containing the simple polysaccharide hyaluronan. These complexes are essential for ovulation and fertilisation in mammals and also form wherever there is inflammation, e.g. in articular joints during arthritis. Detailed structural insights will enable the targeted modulation of hyaluronan cross-linking, to interfere with pathological matrix development and to generate matrices with tailored properties in vitro, e.g. for applications in regenerative medicine and human fertility treatments.
The post-doctoral researcher will be experienced in protein structure determination, ideally using single-particle cryoEM analysis. Knowledge of recombinant protein production, other structural techniques (e.g. Small-Angle X-ray Scattering (SAXS) and X-ray crystallography) and biophysical analysis of protein-ligand interactions are also desirable.
This is a full-time position, funded by the BBSRC, and is available from 1st December 2019, or as soon as possible thereafter, for up to three years.
For more information and to apply, click here.
