Two PhD studentships have become available within a MSCA-ITN grant entitled “DNA helicases in genome maintenance: from molecular and cellular mechanisms to specific inhibitors as potential drugs” (AntiHelix).
The project aims to obtain a detailed picture of the mechanism of action and the physiological role of a number of DNA helicases that are implicated in human diseases, as well as discover specific inhibitors of those enzymes, which can then be tested as novel therapeutic drugs, especially for cancers. For more information on the project, click here.
The roles will focus on the structural, biochemical and cellular characterization, with one studentship focussing on RecQ4 and the other on proteins belonging to the FeS helicase family.
The laboratory is located at the Italian synchrotron facility Elettra, Trieste. Elettra is an international research centre, hosting a large number of scientists and users, with a thriving programme of in-house research. The Structural Biology laboratory includes state-of-the-art facilities for cell biology, molecular biology, large scale protein expression and purification, crystallization and structure determination, biochemical and biophysical charaterization. Trieste is a beautiful, multicultural city, at the border between Italy and Eastern Europe and hosts numerous International research centres, having the highest density of scientists in the whole of Europe!
The application deadline for these positions is 20 December 2019.
For more information and to apply, please contact Silvia Onesti: silvia.onesti@elettra.eu
