View All Magnetic Resonance Techniques at Instruct
Liquid state NMR
NMR spectroscopy provides invaluable insights into the structural and dynamical features of biomolecular systems. We are taking advantage of NMR, combined with other structural biology methods, to investigate molecular properties that are important to achieve a given biological function.
Three spectrometers are installed in the lab: a 500 MHz with room temperature probes, a 600 MHz and a 700 MHz with cryo-probes to achieve highest sensitivity.
500 MHz spectrometer: For experiments that don't need best sensitivity and resolution, a 500 MHZ with two room temperature probes is available (a selective proton probe with carbon and nitrogen decoupling and Z gradients;a broadband probe that allows observation of 19F as well as 31P, 13C and 15N with 1H decoupling.
600 MHz spectrometer: For experiments that need high sensitivity and resolution, the 600 MHz spectrometer with cryogenic probe is available (selective proton CryProbeTM with carbon, nitrogen and deuterium decoupling and Z gradients).
700 MHz spectrometer: For experiments that need extreme sensitivity and resolution, the 700 MHZ spectrometer with a selective proton and carbon CryoProbeTM with nitrogen/carbon/deuterium decoupling and Z gradients.
NMR spectroscopy provides invaluable insights into the structural and dynamical features of biomolecular systems. We are taking advantage of NMR, combined with other structural biology methods, to investigate molecular properties that are important to achieve a given biological function.Two spectrometers are installed in the lab: a 600 MHz armed with a cryo-probe to access the highest sensitivity on 19F and a 700 MHz with cryo-probes to achieve highest sensitivity on 13C or 1H.
